Promises and pitfalls of live attenuated pneumococcal vaccines

Alzheimer’s disease vaccines: promises and pitfalls

Feasibility of immunotherapy for Alzheimer’s disease has been postulated, and numerous strategies of active and passive immunization have been applied in animals and humans. This article summarizes accumulated knowledge in clinical trials and animal experiments, and foresees the future perspective. Clinical trials have clearly shown that clearance of senile plaque amyloid is insufficient for im...

Live Attenuated Measles Mumps and Rubella Vaccines:

Abbreviations: MMR: Measles, Mumps and Rubella; WHO: World Health Organization; SSPE: Subacute Sclerosing Panencephalitis; PAHO: Pan American Health Organization; CRS: Congenital Rubella Syndrome; MR: Measles-Rubella; GSK: GlaxoSmithKline; EZ: Edmonston Zagreb; CEF: Chicken Embryo Fibroblast; IBD: Inflammatory Bowel Disease; CDC: Centers for Disease Control and Prevention; SSPE: Subacute Sclero...

Evaluation of Live Attenuated Measles Vaccines Prepared in Human Diploid Cells for Reimmunization

Live attenuated and inactivated influenza vaccines in children.

BACKGROUND Live attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV) are available for children. Local and systemic immunity induced by LAIV followed a month later by LAIV and IIV followed by LAIV were investigated with virus recovery after LAIV doses as surrogates for protection against influenza on natural exposure. METHODS Fifteen children received IIV followed by LA...

Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster Virus

Since vaccinia virus was first used to protect against smallpox in the eighteenth century, live attenuated vaccines have proved to be highly effective in reducing the morbidity and mortality caused by many human viral pathogens. Contemporary live viral vaccines are designed using several different strategies to achieve attenuation. These basic principles and approaches are illustrated by vaccin...